MULTI-SPECIFIC ANTIGEN-BINDING MOLECULE HAVING ALTERNATIVE FUNCTION TO FUNCTION OF BLOOD COAGULATION FACTOR VIII农业专利-农业专业知识服务系统

发明人:: IGAWA TOMOYUKI,井川智之,SAMPEI ZENJIRO,三瓶全次郎,KOJIMA TETSURO,小嶋哲郎,SOEDA TETSUHIRO,添田哲弘,MUTO ATSUSHI,武藤厚,KITAZAWA TAKEHISA,北澤剛久,NISHIDA YUKIKO,西田由紀子,IMAI CHIFUMI,今井千史,SUZUKI TSUKASA,鈴木司,YO

摘要：: To provide a multi-specific antigen-binding molecule having an alternative function to the function of blood coagulation factor VIII.SOLUTION: The present invention provides a multi-specific antigen-binding molecule with high activity substituting for the function of blood coagulation factor VIII. The molecule is found out among various prepared bispecific antibodies each specifically binding to both the blood coagulation factor IX/activated blood coagulation factor IX and the blood coagulation factor X and having an alternative function to the cofactor function of the blood coagulation factor VIII, i.e., the function of promoting the activation of the blood coagulation factor X by the activated blood coagulation factor IX.SELECTED DRAWING: None【課題】血液凝固第ＶＩＩＩ因子の機能を代替する機能を有する多重特異性抗原結合分子の提供。【解決手段】血液凝固第IX因子/活性化血液凝固第IX因子及び血液凝固第X因子の双方に特異的に結合し、血液凝固第VIII因子の補因子機能、すなわち活性化血液凝固第IX因子による血液凝固第X因子活性化を促進する機能を代替する機能を有する種々の二重特異性抗体を作製し、これらの抗体の中から、見出した血液凝固第VIII因子の機能を代替する活性の高い多重特異性抗原結合分子。【選択図】なし