Disclosed herein are compounds that form covalent bonds with Bruton’s tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.本發明描述與布魯頓氏酪胺酸激酶(Btk)形成共價鍵的化合物。亦描述Btk之不可逆抑制劑。另外，亦描述Btk之可逆抑制劑。亦揭示包括此等化合物的醫藥組合物。揭示單獨或與其他治療劑組合地使用Btk抑制劑治療自體免疫疾病或病狀、異質免疫疾病或病狀、癌症(包括淋巴瘤)及發炎疾病或病狀的方法。
