Steven P. Schwendeman,Ronak B. Shah,Morgan B. Giles,Rae Sung Chang,Anna A. Schwendeman
申请号：
US14537716
公开号：
US20150164805A1
申请日:
2014.11.10
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A drug delivery system comprises a porous, self-healing biodegradable polymer matrix having a ionic, charged, biopolymer and a pH modifying species disposed within the pores. An ionic macromolecule having the opposite charge binds the biopolymer and forms a nonsoluble polyelectrolyte complex. The molecular weight of the biopolymer, the self healing polymer matrix, the concentration of pore forming agent and the concentration of the pH modifying species are selected for optimal binding and release of the macromolecule.
