The United States of America; as Represented by th Secretart; Department of Health and Human Service
发明人:
Jason Marc Goldstein,Conrad P. Quinn,Dennis A. Bagarozzi,Anne E. Boyer
申请号：
US14427329
公开号：
US20160039874A1
申请日:
2013.09.11
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Provided are peptides capable of reducing the ability of antibodies to stimulate the activity of B. anthracis lethal factor. These peptides may be used to reduce activity of LF in a sample containing an LF activity enhancing antibody, to prevent the possibility of LF enhanced activity in a sample or subject, or as a therapeutic to reduce LF activity in a subject that may-have one or more antibodies that enhance LF activity. Also, provided are immunogens that may be used in a vaccine to confer protection to a subject. An immunogen does not include a sequence including the wild-type amino acids present in LF residues 677-680, or mutations of amino acids 677-680 that will also generate antibodies that enhance LF activity.
