DAVIDSON, ALAN HORNSBY,DRUMMOND, ALAN HASTINGS,NEEDHAM, LINDSEY ANN
申请号：
CA2607020
公开号：
CA2607020C
申请日:
2006.05.04
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Covalent conjugation of an alpha amino acid ester to a modulator of theactivity of a target intracellular enzyme orreceptor, wherein the ester group of the conjugate is hydrolysable by one ormore intracellular carboxylesterase enzymes to thecorresponding acid, leads to accumulation of the carboxylic acid hydrolysisproduct in the cell and enables improved or more prolongedenzyme or receptor modulation relative to the unconjugated modulator.
