The invention provides methods for making silicone structures, drug delivery devices and active pharmaceutical agent delivery systems and medical devices containing one or more active pharmaceutical ingredients. The invention provides silicone structures, drug delivery devices and active pharmaceutical agent delivery systems containing one or more active pharmaceutical ingredients. The silicones used in the invention are foaming silicones, which generate void-forming gases which completely volatilize during curing. The silicone structures, drug delivery devices and active pharmaceutical agent delivery systems can be of any shape or size, and are porous, and are capable of being loaded with high doses of the desired drug or drugs. The active pharmaceutical ingredients can be incorporated into the silicone prior to curing, or subsequent to curing, via a soaking process. Additionally, the rate of drug release from the silicone structures, drug delivery devices and active pharmaceutical agent delivery systems of the invention can be controlled by a post-curing membrane or sheath surrounding the structures. Further provided are methods of treating disease in mammals, preventing the onset of disease in mammals and lessening the severity of disease in mammals, by implanting one or more structures, drug delivery devices and active pharmaceutical agent delivery systems into the mammal.