The present disclosure pertains to an airflow shaping system (10) configured to deliver a shaped, pressurized flow of breathable gas to the airway of a subject (12). In some embodiments, the system comprises a pressure generator (14), a subject interface (16), a flow shaper (18), one or more sensors (20), one or more processors (22), electronic storage (24), a user interface (26), and/or other components. Respiratory therapy delivered to a patient's lungs may be enhanced with a shaped flow. A turbulent flow of gas delivered to a patient's lungs is inefficient in the amount of energy required to deliver the gas and because it requires more gas energy to reach the lower airways due to resistance from the airway walls. The system may be used for respiratory therapy applications including pressure support therapy, inexsufflation therapy, airway medication delivery, and/or other applications.