A thienotriazolodiazepine compound of formula (1) or a pharmaceutically acceptable salt thereof or water thereof in combination with one or more chemotherapeutic agents selected from the group consisting of m-TOR inhibitors s and mitotic inhibitors A method of treating triple negative breast cancer in a mammal comprising the step of administering to a patient a pharmaceutically acceptable amount of a solvate or a pharmaceutically acceptable compound thereof: wherein R1 has 1 to 4 carbon atoms R2 is a hydrogen atom； a halogen atom； or an alkyl having 1 to 4 carbon atoms which may be substituted with a halogen atom or a hydroxyl group, and R3 is a halogen atom； a halogen atom, 1 to 4 Alkyl having 1 to 4 carbon atoms, phenyl having 1 to 4 carbon atoms or phenyl optionally substituted by cyano； -NR5- (CH2) m-R6 (wherein R5 is a hydrogen atom or An alkyl having ˜4 carbon atoms, m is an integer from 0 to 4 and R 6 is phenyl or pyridyl optionally substituted with a halogen atom)； or —NR 7 —CO— (CH 2 ) N-R8 (wherein R7 is a hydrogen atom or alkyl having 1 to 4 carbon atoms, n is an integer of 0 to 2, and R8 is phenyl optionally substituted by a halogen atom) Or R4 is-(CH2) a-CO-NH-R9 (wherein a is an integer of 1 to 4 and R9 is an alkyl having 1 to 4 carbon atoms). Hydroxyalkyl having 1 to 4 carbon atoms； alkoxy having 1 to 4 carbon atoms； or alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, substituted with an amino, or hydroxyl group； Optionally phenyl or A lysyl) or -. (CH2) b-COOR10 (wherein, b is an integer from 1 to 4, R10 is an alkyl having a carbon number of 1 to 4).. ]. [Selection] FIG. 18Aｍ－ＴＯＲ阻害剤ｓ及び分裂阻害剤からなる群から選ばれる１種以上の化学療法剤と組み合わせて、式（１）のチエノトリアゾロジアゼピン化合物、又はその医薬上許容される塩又はその水和物又はその溶媒和物である医薬上許容される量の化合物を患者に投与する工程を含む哺乳動物における三種陰性乳癌の治療方法： ［式中、Ｒ１は、１～４の炭素数を有するアルキルであり、Ｒ２は、水素原子；ハロゲン原子；又はハロゲン原子又はヒドロキシル基で置換されていてもよい１～４の炭素数を有するアルキルであり、Ｒ３は、ハロゲン原子；ハロゲン原子、１～４の炭素数を有するアルキル、１～４の炭素数を有するアルコキシ又はシアノで置換されていてもよいフェニル；－ＮＲ５－（ＣＨ２）ｍ－Ｒ６（式中、Ｒ５は、水素原子又は１～４の炭素数を有するアルキルであり、ｍは、０～４の整数で
