Rotational intravascular ultrasound (IVUS) imaging devices, systems, and methods are provided. Some embodiments of the present disclosure are particularly directed to compact and efficient circuit architectures and electrical interfaces for polymer piezoelectric micromachined ultrasonic transducers (PMUTs) used in rotational IVUS systems. In one embodiment, a rotational intravascular ultrasound (IVUS) device includes: a flexible elongate member a piezoelectric micromachined ultrasound transducer (PMUT) coupled to a distal portion of the flexible elongate member and an application-specific integrated circuit (ASIC) coupled to the distal portion of the flexible elongate member. The ASIC is electrically coupled to the PMUT and includes a pulser, an amplifier, a protection circuit, and timing and control circuitry for coordinating operation of the pulser, amplifier, and protection circuit.
