The Board of Trustees of the Leland Stanford Junior University
发明人:
Daniel Mark Corey,Aaron Michael Ring,Irving L. Weissman
申请号：
US15575927
公开号：
US20180147257A1
申请日:
2016.05.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
BTN3A ectodomain polypeptides are provided, which comprise a BTN3A ectodomain (e.g., a BTN3A1, BTN3A2, or BTN3A3 ectodomain) and lack a BTN3A transmembrane domain (e.g., a BTN3A1, BTN3A2, or BTN3A3 transmembrane domain). Compositions and methods are provided for activating an antigen presenting cell (APC). In some cases, the APC is activated in vivo. For example, in some cases, APC activity is stimulated (an APC is activated) in a mammal by administering a pharmaceutical composition comprising a BTN3A ectodomain polypeptide.
