THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
NECKERS, JANE B.,KIM, YEONG SANG,LEE, SUNMIN,KUMAR, VINEET,MALHOTRA, SANJAY V.
申请号：
CA2839301
公开号：
CA2839301A1
申请日:
2012.06.15
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Disclosed are compounds which are nuclear receptor modulators that can act as antagonists to the androgen receptor, for example, a compound of Formula I: wherein R1 to R5 and X1 to X5 are as described herein, as well as pharmaceutically acceptable salts, solvates, and stereoisomers thereof. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment for cancers, including prostate cancers, other nuclear receptor mediated cancers, and other conditions, are also disclosed.
