Sasha H. Bakhru,Bryan E. Laulicht,Xuan Jiang,Lirong Chen,Solomon S. Steiner
申请号：
US14766347
公开号：
US20150374825A1
申请日:
2014.02.06
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Stabilized formulations containing a peptide, such as a glucagon, are described herein. The formulations are in the form of a solution or suspension, which exhibit ttle or no chemical degradation and/or aggregation of the peptide over an extended period of time. In some embodiments, the formulations are in the form of a solution containing the peptide, a solvent such as glycerin, and one or more thermal stabilizers. In other embodiments, the formulation is in the form of a suspension containing nano- and/or microparticles containing the peptide suspended in a non- aqueous, non-solvent. The nano- and/or microparticles can be prepared by micronizing the peptide with one or more humectants, such as salts, sugars, water-soluble polymers, and combinations thereof which increase the rate of dissolution of the peptide upon administration.
