Compositions and methods for immunostimulatory RNA oligonucleotides

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专利权人:

Veit Hornung;Gunther Hartmann

发明人:

Gunther Hartmann,Veit Hornung

申请号：

US12066906

公开号：

US08815503B2

申请日:

2006.09.14

申请国别(地区):

US

年份:

2014

代理人:

摘要：

The present invention provides 4-nucleotide (4mer) RNA motifs that confer immunostimulatory activity, in particular, IL-12-inducing activity to a single-stranded RNA oligonucleotide. The present invention also provides single-stranded RNA oligonucleotides, including antisense RNA, with high or low immunostimulatory activity. The present invention further provides the use of the RNA oligonucleotides of the invention for therapeutic purposes.

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中国工程科技知识中心

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http://www.ckcest.cn/home/