BROOKS, Carl A.,CHEUNG, Mui,EIDAM, Hilary S.,FOX, Ryan M.,HILFIKER, Mark A.,MANAS, Eric S.,YE, Guosen
申请号：
ES11760129
公开号：
ES2561674T3
申请日:
2011.03.23
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of Formula I: ** Formula ** wherein: R1 is independently H, CF3 or Me； R2 is independently OH, C1-4alkyl, C1-4alkyl, CH2OH, F, CH2C1-4alkyl, CF3 or CF2H； R3 is morpholinyl, piperidinyl, pyrrolidinyl or hexahydroazepinyl； all of which may be unsubstituted or substituted with one or two R8； or R3 is N (C1-6 alkyl) 2, wherein C1-6 alkyl may be unsubstituted or substituted with OH or -OCH3； R4 is CF3, halo, OMe or alkyl； R5 is halo, cyano, CF3, C1-5 alkyl, C2-4 alkenyl, pyrrolidinyl, morpholinyl, piperidinyl, phenyl, pyridyl, pyrazolyl, pyrrolyl, piperazinyl, pyrimidinyl, OH, O-C1-4-OR6 alkyl, OCF3, OCH2CF3 , OCH2CN, OR6 or CH2R9； wherein pyrrolidinyl, morpholinyl, piperidinyl, phenyl, pyridyl, pyrazolyl, pyrrolyl, piperazinyl or pyrimidinyl may be unsubstituted or substituted with one or two halo, OH, OR6 or R6； R6 is independently C1-4 alkyl, C3-6 cycloalkyl； R7 is independently halo, methyl or OMe； R8 is independently OH, C1-4alkyl, C1-4alkyl, CH2OH, F, CH2C1-4alkyl, CF3 or CF2H； R9 is independently pyrrolidinyl, morpholinyl or piperidinyl； R10 is independently H, CF3 or Me； n is independently 0, 1 or 2； X is N or C； y is 1 or 2； or one of its pharmaceutically acceptable salts.Un compuesto de Fórmula I:**Fórmula** en donde: R1 es independientemente H, CF3 o Me； R2 es independientemente OH, Oalquilo C1-4, alquilo C1-4, CH2OH, F, CH2Oalquilo C1-4, CF3 o CF2H； R3 es morfolinilo, piperidinilo, pirrolidinilo o hexahidroazepinilo； todos los cuales pueden estar sin sustituir o sustituidos con uno o dos R8； o R3 es N(alquilo C1-6 )2, en donde alquilo C1-6 puede estar sin sustituir o sustituido con OH o -OCH3； R4 es CF3, halo, OMe o alquilo； R5 es halo, ciano, CF3, alquilo C1-5, alquenilo C2-4, pirrolidinilo, morfolinilo, piperidinilo, fenilo, piridilo, pirazolilo, pirrolilo, piperazinilo, pirimidinilo, OH, O-alquil C1-4-OR6, OCF3, OCH2CF3, OCH2CN, OR6 o CH2R9； en donde el pirrolidinilo, morfolinilo, piperidinilo, fenilo, piridilo, pirazolilo, pirrolilo, piperazini
