Provided herein are methods, compositions, and kits for treating myeloproliferative disorders or neoplasms, including polycythemia vera, primary myelofibrosis, thrombocythemia, and essential thrombocythemia. Also provided herein are methods for treating cancers. Such methods may include the use of a JAK inhibitor and a PI3K inhibitor. Such methods may include the use of an anti-CD20 antibody and a PI3K inhibitor. Provided herein are also compositions, articles of manufacture and kits related thereto.本發明提供用於治療骨髓增生性病症或腫瘤(其包括真性紅血球增多症(polycythemia vera)、原發性骨髓纖維化(primary myelofibrosis)、血小板增多症(thrombocythemia)及原發性血小板增多症(essential thrombocythemia))之方法、組成物及套組。本發明亦提供用於治療癌症的方法。該等方法可包括使用JAK抑制劑及PI3K抑制劑。該等方法可包括使用抗CD20抗體及PI3K抑制劑。本發明亦提供組成物、與其相關之製品及套組。
