An exemplary embodiment of an anti-fatigue device includes a framework worn adjacent a body of a user and interaction of a cable and the framework provides an anti-gravity support of the body that reduces user fatigue from an activity the user performs. In another exemplary embodiment, the anti-fatigue device includes a head support halo coupled to the framework, the head support halo provides an anti-gravity support of the head that reduces user fatigue while the user performs the activity. In an alternative exemplary embodiment, the anti-fatigue device includes a leg support that substantially secures the framework adjacent the body while the user stands to perform the activity. In yet another exemplary embodiment, the anti-fatigue device includes a seat plate worn adjacent a buttock of the user substantially secures the framework adjacent the body while the user sits on the buttock to perform the activity.