In the case that [project] with a distance from the irradiation portion of optical fiber is until the diseased tissue even separate, the operation that the PDD diagnostic devices and fluorescence diagnostic mode of same fluorescence detection sensitivity can be obtained when the irradiation portion of optical fiber is irradiated close to diseased tissue aobvious provides diagnostic system in the art combined by micro mirror. Light that [solution] assembles in diseased tissue increase the light source portion 1 for going out light in sense substance and increase the test section 13 of the fluorescence 11 generated in sense substance from light and be emitted be connected on incident dual-purpose end dust instrument excitation light irradiation/fluorescence detection dual-purpose optical cable 8 is defence, go out the excitation light of light by fiber optics leaded light from light source portion, the excitation light being emitted, it is irradiated in the state of becoming because of dust instrument, the light integrated in diseased tissue is encouraged to increase sense substance, fluorescence Jie being activated is launched into, by fiber optics leaded light, the diagnostic device of fluorescence and the combination unit for the surgical operation microscope having are detected in test section. [selection figure] Fig. 7