SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH;KOFF, ANDREW;KIYOKAWA, HIROAKI
发明人:
KOFF, ANDREW,KIYOKAWA, HIROAKI
申请号：
WO1997US05921
公开号：
WO9738091(A1)
申请日:
1997.04.10
申请国别(地区):
世界知识产权组织国际局
年份:
1997
代理人:
摘要：
This invention provides a recombinant non-human animal lacking the cyclin-dependent kinase inhibitor function of p27<Kip1> and the method for producing the same. This invention also provides a method for increasing the proliferation of the thymic T-cells by treating the thymic T-cells to eliminate the cyclin-dependent kinase inhibition function of p27<Kip1>. This invention also provides a method for increasing the proliferation of hematopoietic cells which comprises treating the hematopoietic cells to eliminate the cyclin-dependent kinase inhibitor function of p27<Kip1>, thereby increasing the proliferation of the hematopoietic cells. This invention further provides a method for alleviating symptoms of an AIDS patient comprising steps of: a) collecting the lymphocytes or other cells from an AIDS patient; b) treating the collected cells to eliminate the cyclin-dependent kinase inhibition function of p27<Kip1>; and c) re-introducing the treated cells to the AIDS patient.
