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COMPOSITIONS COMPRISING A RECOMBINANT ADENOVIRUS AND AN ADJUVANT
专利权人:
发明人:
申请号:
EP07727347.2
公开号:
EP1998804B1
申请日:
2007.03.26
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
The invention relates to pharmaceutical compositions comprising replication-defective adenoviruses, said adenoviruses generally comprising an adenoviral genome wherein a heterologous nucleic acid of interest is incorporated, and wherein said nucleic acid typically encodes an antigen. Such compositions are suitable for vaccination purposes. The pharmaceutical compositions of the present invention further comprise an adjuvant, which stimulates and increases the immune response towards the antigen encoded by the heterologous nucleic acid. Preferred adjuvants are oil-emulsion based adjuvants and aluminium-based adjuvants.
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