The present invention is in the field of monoclonal antibodies suitable for passive immunotherapy of Herpes Simplex Virus infections and relates to human monoclonal antibodies or fragments of said antibodies, which bind and neutralize HSV-1 and HSV-2, and their use in the prophylaxis or treatment of HSV-1 or HSV-2-associated diseases.本發明係關於適合用於單純皰疹病毒感染之被動式免疫治療的單株抗體的領域且係關於人類單株抗體或該抗體之片段,其與HSV-1及HSV-2結合並中和HSV-1及HSV-2、以及其等於預防或治療HSV-1或HSV-2相關性疾病的用途。