PILLAY VINESS,DU TOIT LISA CLAIRE,CHOONARA YAHYA ESSOP,CHOONARA BIBI F,KUMAR PRADEEP,KONDIAH PIERRE PAVAN DEMARCO
申请号：
IN201817003018
公开号：
IN201817003018A
申请日:
2018.01.25
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
The invention relates to an oral polymeric pharmaceutical dosage form which comprises a thermoresponsive eutectic composition which is solid at or about room temperature and fluid at or about body temperature the eutectic composition mixed together with a crosslinking agent and an active pharmaceutical ingredient (API) to form an API loaded region and a porous polymeric composition at least partially surrounding the API loaded region to protect the API when the dosage form is in a stomach of the human or animal body the porous polymeric composition allowing the ingress of water to contact the crosslinking agent thereby facilitating the crosslinking agent to cause crosslinking of the porous polymeric composition which crosslinked porous polymeric composition allows controlled egress of API via egress of fluid thermoresponsive eutectic composition at the intestine. In a preferred embodiment the dosage form further comprises a coating there around.
