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R–n–) 3–3–) 7–מתיל–1h–אינדאזול–5–איל)–1–(4–(1–מתילפיפרידינ–4–איל)פיפראזיינ–l –איל) 1–אוקסופרופאנ–2–איל)–4–(2–אוקסו–1,2–דיהידרוקווינולינ–3–איל)פיפרידינ–1–קרבוקסאמיד, הרכבים רוקחי ים המכילים אותו ןשימושם
专利权人:
BRISTOL-MYERS SQUIBB COMPANY
发明人:
申请号:
IL22166512
公开号:
IL221665A
申请日:
2012.08.27
申请国别(地区):
IL
年份:
2016
代理人:
摘要:
The disclosure generally relates to the compound of formula I, (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide, including pharmaceutically acceptable salts, which is a CGRP-receptor antagonist. The disclosure also relates to pharmaceutical compositions and methods for using the compound in the treatment of CGRP related disorders including migraine headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and cancer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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