The present invention provides methods for treating OFF episodes in a Parkinson s Disease patient comprising administering levodopa to the pulmonary system of a patient wherein after administration the patient s Unified Parkinson s Disease Rating Scale (UPDRS) Part 3 score is improved by for example at least about 5 points as compared to placebo control and/or as compared to the patient s UDPRS Part 3 score prior to administration. The invention also provides methods of reducing mean daily OFF time in a Parkinson s patient.