UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION;NATIONAL RESEARCH COUNCIL OF CANADA
发明人:
HINCK, ANDREW PETERSON,SULEA, TRAIAN
申请号：
CA3041727
公开号：
CA3041727A1
申请日:
2017.11.17
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Recombinant transforming growth factor (TGF)-ß monomers modified to inhibit dimerization and block TGF-ß signaling are described. The recombinant TGF-ß monomers lack the ability to bind and recruit TGF-ß type I receptor (?ß?), but retain the capacity to bind the high affinity TGF-ß type II receptor (?ß??), and in some instances, include mutations that increase their affinity for ?ß??. Nucleic acid molecules and vectors encoding the recombinant TGF-ß monomers are also described. Isolated cells, such as T cells, can be re-programmed with a TGF-ß monomer-encoding nucleic acid or vector to secrete the monomer. Use of the recombinant TGF-ß monomers and/or cells producing the recombinant TGF-ß monomers, to inhibit TGF-ß signaling, such as to treat disorders associated with aberrant TGF-ß signaling, are also described.
