The present invention relates to the compound of Formulas I and its officinal salts, can treat the disease that aldosterone mediates with what. The invention further relates to the specific diastereomer and enantiomer of the compound, the method for preparing compound of formula I, they with what treat and prevent above-mentioned disease and with what prepare the potential use of drug for this purpose and comprising the pharmaceutical composition of compound of formula I.本發明涉及式I的化合物,以及其可藥用鹽,其可以用於治療醛甾酮介導的疾病。本發明還涉及該化合物的特定非對映體和對映體、製備式I化合物的方法、它們用於治療和預防上述疾病和爲了該目的用於製備藥物的潜在用途以及包含式I化合物的藥物組合物。