A toothbrush flosser has a handle having a pair of ends, namely a flossing head end and a brush head end. A toothbrush head is mounted to the brush head end, and the toothbrush head includes bristles. A flossing head retainer is mounted on the flossing head end. A flossing head is retained to the flossing head retainer at a connection area formed on the flossing head. The flossing head has a pair of arms that hold a floss in an extended position. The toothbrush flosser optionally includes a flossing head retainer groove formed on the connection area. The flossing head retainer groove has an inside sidewall, an outside sidewall opposing the inside sidewall and a lower wall.