JOHNSON LESLIE S.,BONVINI EZIO,MOORE PAUL A.,SHAH KALPANA,LI JONATHAN C.
申请号：
CL2016003050
公开号：
CL2016003050A1
申请日:
2016.11.28
申请国别(地区):
CL
年份:
2017
代理人:
摘要：
The present invention relates to Tri-Specific Binding Molecules, which are multi-chain polypeptide molecules that possess three Binding Domains and are thus capable of mediating coordinated binding to three epitopes. The Binding Domains may be selected such that the Tri-Specific Binding Molecules are capable of binding to any three different epitopes. Such epitopes may be epitopes of the same antigen or epitopes of two or three different antigens. In a preferred embodiment, one of such epitopes will be capable of binding to CD3, the second of such epitopes will be capable of binding to CD8, and the third of such epitopes will be capable of binding to an epitope of a Disease-Associated Antigen. The invention also provides a novel ROR1-binding antibody, as well as derivatives thereof and uses for such compositions.La presente solicitud menciona una molécula de unión tri-especifica, capaz de unirse a tres diferentes epitopos caracterizada porque comprende cuatro cadenas distintas de polipeptido enlazadas entre si. Menciona que los dominios pueden unirse a dos epitopos de antigenos de cáncer y un tercero a un epitopo a un antígeno de célula efectora. También menciona el orden de los dominios de cada cadena de polipeptido
