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compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, and use of a pharmaceutical composition
- 专利权人:
- MERCK SHARP & DOHME CORP.
- 发明人:
- Hannah D.G.F. Lehman,Joseph E. Pero,Mark E. Layton,Michael A. Rossi,Michael J. Kelly, III
- 申请号:
- BR112015008987
- 公开号:
- BR112015008987A2
- 申请日:
- 2013.10.23
- 申请国别(地区):
- BR
- 年份:
- 2017
- 代理人:
- 摘要:
- 1/1 summary “compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, and use of a pharmaceutical composition” are disclosed compounds of the formula a and in formula a: in a1 a2 b1 c that â € ˜heteroaryl-1â € ™, r, r, r, r, and r are defined herein, novel compounds which have properties to block nav 1.7 channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of the formulas a and a or their salts, and methods of treating neuropathic pain disorders using the same.1 / 1 resumo “composto ou um sal farmaceuticamente aceitã�vel do mesmo, composiã‡ãƒo farmacãšutica, e, uso de uma composiã‡ãƒo farmacãšuticaâ€� a b sã£o divulgados compostos da fã³rmula a e fã³rmula a : em a1 a2 b1 c que “heteroarila-1â€�, r , r , r , e r sã£o aqui definidos, compostos novos estes que tãªm propriedades para bloquear canais de ãon nav 1.7 encontrados nos neurã´nios perifã©ricos e simpã¡ticos. tambã©m sã£o descritos formulaã§ãµes a b farmacãªuticas compreendendo os compostos das fã³rmulas a e a ou seus sais, e mã©todos de tratamento de distãºrbios de dor neuropã¡tica usando os mesmos.
- 来源网站:
- 中国工程科技知识中心
- 来源网址:
- http://www.ckcest.cn/home/