NISSAN CHEMICAL INDUSTRIES LTD.;TAISHO PHARMACEUTICAL CO. LTD.;TAKEHISA IWAMA;NOBUTOMO TSURUZOE
发明人:
TAKEHISA IWAMA,NOBUTOMO TSURUZOE
申请号：
IL17647306
公开号：
IL176473A
申请日:
2006.06.21
申请国别(地区):
IL
年份:
2013
代理人:
摘要：
To provide an antineutrophilia agent effective for treatment of development and progress of acute infections, collagen diseases (chronic rheumatoid arthritis, Wegener's granulomatosis and Behcet's disease), chronic obstructive pulmonary disease (COPD), chronic bronchitis, pulmonary emphysema, small airway disease, gout, Cushing's syndrome, myelofibrosis, neoplastic neutrophilia, polycythemia vera and diseases caused by administration of steroid drugs. An antineutrophilia agent containing a 3(2H)-pyridazinone compound represented by the formula (I) or a pharmaceutically acceptable salt thereof [wherein each of R 1 , R 2 and R 3 is independently a hydrogen atom or a C 1-6 alkyl group, X is a halogen atom, cyano or a hydrogen atom, Y is a halogen atom, trifluoromethyl or a hydrogen atom, and A is a C 1-8 alkylene which may be substituted with a hydroxyl group].
