Vaccin contre la grippe avec adjuvant d'huile-en-eau

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专利权人:

GlaxoSmithKline Biologicals S.A.

发明人:

申请号：

EP11194315.5

公开号：

EP2455101A2

申请日:

2008.04.16

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

The present invention provides an immunogenic influenza composition in a dose volume suitable for human use, comprising an influenza virus antigen or antigenic preparation thereof and an adjuvant composition comprising an oil-in-water emulsion, wherein said oil-in-water emulsion comprises a metabolisable oil at a level of below 11 mg and an emulsifying agent at a level of below 5 mg and optionally a tocol or a sterol at a level of below 12 mg. Suitably the amount of influenza antigen per strain per dose is 15 pg HA or a low amount such as less than 15 pg HA.

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