The present invention is aimed to scientifically examine a change of a living body by exposing the living body in an electric field generated by a high voltage (such an action will be hereinafter also referred to “electric field exposure”), elucidate a detailed mechanism of action of a therapeutic effect by a potential therapeutic device, and find out its new use applications. The present invention is to provide a method for increasing a bio-derived low molecular weight compound including exposing a living body in an electric field generated by impressing a high voltage between electrodes or between an electrode and a ground and a method for treating/improving a disease or a symptom thereof, the method including exposing a patient of a disease selected from bulimia, metabolic syndrome, obesity, diabetes, hyperlipemia, arteriosclerosis, headache, lumbago, stomachache, neuralgia, dementia, and sarcopenia in an electric field generated by impressing a high voltage of 9,000 to 18,000 V between electrodes or between an electrode and a ground.
