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METHOD OF USING HISTONE DEACETYLASE INHIBITORS AND MONITORING BIOMARKERS IN COMBINATION THERAPY
专利权人:
INC.;PHARMACYCLICS
发明人:
ADIMOOLAM, SHANTHI,BUGGY, JOSEPH, J,MAGDA, DARREN,MILLER, RICHARD
申请号:
NZ57842807
公开号:
NZ578428A
申请日:
2007.12.09
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Provided is the use of a therapeutically effective amount of a histone deacetylase (HDAC) inhibitor of formula (I) with defined substituents, and a treatment capable of damaging cellular DNA for the manufacture of a medicament for treating a cancer in which RAD51 is overexpressed. Further provided is a corresponding composition comprising two coatings of drugs for two-stage release of the drugs.
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