Systems and methods for performing radiation treatment planning are provided. An exemplary system may include a processor device communicatively coupled to a memory device and configured to perform operations when executing instruction stored in the memory device. The operations may include receiving a reference treatment plan including one or more dose constraints and determining, based on the reference treatment plan, segment information of a plurality of radiation beams. The operations may also include determining a fluence map for each of the plurality of radiation beams based on the one or more dose constraints using a fluence map optimization algorithm. The operations may also include determining a dose distribution based on the fluence maps of the plurality of radiation beams. The operations may also include determining at least one beam modulation property of a new treatment plan using a warm-start optimization algorithm based on the segment information and the dose distribution.
