An isolator system (100) includes: a substantially box-shaped isolator (110) including a work space (A) isolated from its surroundings a sterilizing unit (140) configured to spray a sterilizing mist from a nozzle (143) mounted within the isolator (110), the sterilizing mist being obtained by converting a sterilizing liquid into mist and a control unit (160) configured to control an operation of the sterilizing unit (140), wherein the sterilizing unit (140) is configured to spray the sterilizing mist intermittently when spraying.