Described here are methods to treat Disorders using compounds that modulate striatal Enriched tyrosine phosphatase (STEP). The following example Disorders including Schizophrenia and Cognitive deficits.Claim 1: a compound of formula (1) or a Salt thereof, where a is CR4 or N b is aryl or heteroaryl, ciclilo of 5 or 6 members M is 0, 1, 2, 3, 4 or 5 e is an aryl or heteroaryl 5 members n is 0, 1, 2, 3 or 4 when e is aryl, N is 0, 1, 2, 3 or 4 and when e is a heteroari The 5 members, N is 0, 1, 2 or 3 l is NR5, S,Or a direct link one of X and Z is N and the other is CH p is 0, 1, 2, 3 or 4 each R1, R2 and R3 independently alkyl is C1 - C2 - alquenilo 8, 8, 8 alquinilo C2 -, aryl, heteroaryl, ciclilo, heterociclilo, arylalkyl, heteroarilalquilo, ciclilalquilo, heterociclilalquilo, Halo, haloalquilo, Haloalcoxi, aminoalquilo, alquilaminoalquilo, dialquilaminoalquilo hidroxialquilo alkoxyalkyl esters,,,Sililoxi, sililoxialquilo, sililoxialquinilo, sililalcoxi, sililalcoxialquilo, - CN, Oxo, NO2 -, - C (o) - C (ORA, and nrbrb (NRCC), - and - RC), nrbrb, OC (NRCC) nrbrb - (OR) - so2nrbrb ORC, - nrcso2rc - (NRCC) nrbrb - ORD, SRD -, - C (re -) or s (QRF), where each of them is optionally substituted With 1 - 3 where two R6, R1, along with the Atoms to which they are UnitedThey form a ring ciclilo heterociclilo, aryl or heteroaryl substituted, optionally alkyl R4 is Hydrogen, C1 C2 alquenilo - 8 - 8 - 8 alquinilo C2, aryl, heteroaryl, ciclilo, heterociclilo, arylalkyl, heteroarilalquilo, ciclilalquilo, heterociclilalquilo, Halo, haloalquilo, haloalc Oxy, aminoalquilo, alquilaminoalquilo, dialquilaminoalquilo hidroxialquilo alkoxyalkyl esters,,,Sililoxi, sililoxialquilo, sililalcoxi, sililalcoxialquilo, - CN, - NO2, - C (o) - C (ORA, and nrbrb (NRCC), - and - RC), nrbrb, OC (NRCC) nrbrb - (OR) - so2nrbrb ORC , - , nrcso2rc - nrbrb NRCC, (and), SRD ord -, -, - C (re -) or s (QRF), where each of them is optionally substituted with 1 - 3 is Hydro R5 R6 Geno or when M is not 0,A
