Described herein are compositions and methods for the inhibition of miR-122 activity. The compositions have certain nucleoside modifications that yield potent inhibitors of miR-122 activity. The compounds may comprise conjugates to facilitate delivery to the liver. The compositions may be administered to subjects infected with hepatitis C virus, as a treatment for hepatitis C virus and related conditions.在此描述了用於抑制miR-122活性之組合物和方法。該等組合物具有產生miR-122活性有效抑制劑的某些核苷修飾。該等化合物可以包含共軛物以促進向肝臟遞送。可以向被丙型肝炎病毒感染的受試者給藥該等組合物作為用於丙型肝炎病毒和相關病狀之治療。
