The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.本發明提供一類新穎化合物、包含該等化合物之醫藥組合物及使用該等化合物來治療或預防與Toll樣受體(包括TLR7及TLR8)相關之疾病或病症的方法。在一態樣中,該等化合物可用作用於增強疫苗效力之佐劑。