Monoclonal Antibodies specific for the antigen - 1 m2 of the Respiratory syncytial virus (RSV), produced and secreted by hybridoma Cell, useful for Detection and diagnosis of the infection caused by RSV
ALEXIS MIKES KALERGIS PARRA,SUSAN MARCELA BUENO RAMIREZ,JORGE EUGENIO MORA ALARCON,ROBERTO SEBASTIAN GOMEZ JOHNSON
申请号：
ARP120104435
公开号：
AR088987A1
申请日:
2012.11.23
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
This refers to the use of specific Monoclonal Antibodies to Respiratory syncytial virus (RSV). Specifically, an IgG2a monoclonal antibody secreted by the hybridoma cell line 8a4 / G9 specifically directed to the viral Antigen m2 - 1, which is associated to the capsid of the virus.Antibodies can be used for Testing the Detection and / or determination of RSV infection. These Antibodies are found in Pure and contaminant free of any other Biological material.In Another aspect, a method is provided for the Prevention and Treatment of the infection caused by Respiratory syncytial virus (RSV) in a host, which comprises administering a composition comprising the Monoclonal Antibodies secreted by the hybridoma 8a4 / G9 in OJ SIS sufficient to prevent disease.The Humanized Antibody can be to minimize the possibility of an immune response against him in the patient who uses it. In addition, providing the formulation of any Pharmaceutical Form of the Monoclonal Antibodies secreted by the hybridoma 8a4 / G9, which are suitable for the Treatment or prevention of a disease caused by RSV.It also provides methods for diagnosis and detection of viral antigens of RSV in biological samples, in which the use of Monoclonal Antibodies by hybridoma cells produced and secreted 8a4 / G9.La presente se refiere al uso de anticuerpos monoclonales específicos para el virus respiratorio sincicial (VRS). Concretamente, a un anticuerpo monoclonal IgG2A secretado por la línea celular de hibridoma 8A4/G9 dirigido específicamente para el antígeno viral M2-1, el cual está asociado a la nucleocápside del virus. Los anticuerpos pueden ser utilizados para ensayos de detección y/o determinación de infección por VRS. Dichos anticuerpos se encuentran en estado puro y libre de cualquier otro material biológico contaminante. En otro aspecto, se proporciona un método para prevención y tratamiento de la infección causada por virus respiratorio sincicial (VRS) en un huésped dado, el cual comprende la admini
