The present invention relates to a slow-release pharmaceutical composition containing, as an active ingredient, N-desalkyl quetiapine which is an active metabolome of quetiapine. More specifically, the present relates to a slow-release pharmaceutical composition containing N-desalkyl quetiapine as an active ingredient. According to the present invention, contained as slow-release diluting agents are one or more molecules selected among hydroxypropyl methylcellulose (HPMC), poly(meth) acrylates (Eudragit L), and poly vinyl acetate-poly vinylpyrrolidone (Kollidon SR). According to the present invention slow-release preparation composed of N-desalkyl quetiapine allows a distinctly retarded elution pattern of a formulation to be found by means of noticeably delayed drug release.COPYRIGHT KIPO 2016본 발명은 quetiapine의 활성 대사체인 N-desalkylquetiapine을 활성성분으로 포함하는 서방성(徐放性) 약제학적 조성물에 관한 것이다.본 발명은, N-desalkylquetiapine을 활성성분으로 포함하는 서방성 약제학적 조성물인 것을 특징으로 한다.또한 본 발명은 hydroxypropylmethylcellulose(HPMC), poly(meth)acrylates(Eudragit L) 및 polyvinyl acetate-polyvinyl pyrrolidone(Kollidon SR) 중에서 선택되는 하나 또는 둘 이상이 서방화 부형제로 포함되는 것을 특징으로 한다.
