ISOLATION OF ATRARIC ACID, SYNTHESIS OF ATRARIC ACID DERIVATIVES, AND USE OF ATRARIC ACID AND THE DERITIVES THEREOF FOR THE TREATMENT OF BENIGN PROSTATE HYPERPLASIA, PROSTATE CARCINOMA AND SPINOBULBAR MUSCULAR ATROPHY
Use of 2,4-dihydroxy-3-methylbenzoate derivatives (I) for preparing medicaments or as basic substance for the development of other agents used for treating benign prostate hyperplasia, prostate carcinoma or spinobulbar muscular atrophy. Use of 2,4-dihydroxy-3-methylbenzoate derivatives of formula (I) for preparing medicaments or as basic substance for the development of other agents used for treating benign prostate hyperplasia, prostate carcinoma or spinobulbar muscular atrophy. R 11-4C alkyl； and R 2H, CH 3, ethyl or propyl. Independent claims are included for: (1) a medicament for treating benign prostate hyperplasia, prostate carcinoma or spinobulbar muscular atrophy, comprising (I)； (2) (I) (where R 1>； is iso-propyl, geranyl or ethylbenzol sulfonamide)； (3) a method for the isolation of atraric acid from biological material comprises crushing biological material, extracting biological material with a solvent, which is monovalent 1-4C alcohol or volatile, (partly)-halogenated 1C-hydrocarbon, fractionating the extract and isolating atraric acid from the biological material containing fraction； and (4) a method for the preparation of atraric acid derivatives comprising stirring the atraric together with an equimolar amount of alkali hydroxide or alkaline-earth hydroxide in a solution of a primary aliphatic alcohol and isolating the atraric acid derivatives from the reaction mixture. [Image] ACTIVITY : Muscular-Gen.； Cytostatic. MECHANISM OF ACTION : Estrogen receptor agonist.본 발명은 생물학적 재료로부터 아트릭산을 분리하는 방법, 아트라릭산 유도체, 그들의 화학적 합성 및, 전립선비대증, 전립선암종, 또는 척수연수 근위축증의 치료 또는 치료용 약제의 제조를 위한 아트라릭산 및 그 유도체의 용도, 및 전립선비대증, 전립선암종, 또는 척수연수 근위축증 치료용의 다른 약제의 개발을 위한 기초 물질로서 아트라릭산 및 그 유도체의 용도에 관한 것이다.
