STRUCTURE-BASED PEPTIDE INHIBITORS OF P53 AGGREGATION AS A NEW APPROACH TO CANCER THERAPEUTICS

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专利权人:

发明人:

David S. Eisenberg,Alice Soragni,Lin Jiang

申请号：

US15877134

公开号：

US20180155396A1

申请日:

2018.01.22

申请国别(地区):

US

年份:

2018

代理人:

摘要：

This invention relates, e.g., to an inhibitory peptide or CPP inhibitor which specifically binds to p53 having an aberrant conformation (e.g., is aggregated or misfolded) and inhibits p53 amyloidogenic aggregation or restores proper folding of the misfolded protein. Methods of using the inhibitory peptide or CPP inhibitor (e.g. to treat subjects having tumors that comprise aggregated p53) are described.

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中国工程科技知识中心

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http://www.ckcest.cn/home/