Cytotoxic mediation of cells demonstrating surface expression of CD44农业专利-农业专业知识服务系统

发明人:: ヤング、デイヴィッド、エス．、エフ．,フィンドレイ、ヘレン、ピー．,ハーン、スーザン、イー．,セチェット、リサ、エム．,マコンキー、フォルトゥナタ,ヤング、デイヴィッド、エス.、エフ.,フィンドレイ、ヘレン、ピー.,ハーン、スーザン、イー.,セチェット、リサ、エム.

摘要：: This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumour cells evidencing surface expression of CD44； and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays which utilize the CDMAB of the instant invention.