A computer assisted sedation system and methods for use by a non-anesthetist procedural physician comprising an electronic controller for a drug infusion system for infusing a sedative, analgesic and/or amnestic drug to a patient having data monitors for determining the patient' physiological data and transmitting same to the controller for determining whether the patient's physiological condition is normal and if not, for signaling an alarm and providing instructions to a non-anesthesiologiest procedural physician to return the patient to a normal condition.