Sachin S. Talathi,Dong-Uk Hwang,William L. Ditto,Paul R. Carney,Mark Spano
申请号：
US12917321
公开号：
US08447407B2
申请日:
2010.11.01
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Neuronal excitation and inhibition of the brain is tracked in the hippocampal CA1 network during a latent period, wherein biomarkers are observed which include a sustained increase in the firing rate of the excitatory postsynaptic field activity, paired with a subsequent decrease in the firing rate of the inhibitory postsynaptic field activity the mean amplitude profiles of both fEPSP and fEPSP field potential activity during the latent period have characteristic shapes both excitatory and inhibitory CA1 field activity firing rates are observed to follow a circadian rhythm that drifts during epileptogenesis the circadian rhythms described are in-phase in controls and anti-phase during epileptogenesis and the fEPSP rate drifts from a circadian rhythm to a greater extent than the fEPSP rate. An additional biomarker is a change in a circadian rhythm of core body temperature. Therapeutic measures can include thermal, chemical, or electrical modulation, in an open or closed loop process.
