Methods for purification of messenger rna

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专利权人:

发明人:

HEARTLEIN MICHAEL,DEROSA FRANK,DIAS ANUSHA,KARVE SHRIRANG

申请号：

IN9359/DELNP/2015

公开号：

IN2015DN09359A

申请日:

2015.10.08

申请国别(地区):

IN

年份:

2016

代理人:

摘要：

THE PRESENT INVENTION PROVIDES, AMONG OTHER THINGS, METHODS OF PURIFYING MESSENGER RNA (MRNA) INCLUDING THE STEPS OF SUBJECTING AN IMPURE PREPARATION COMPRISING IN VITRO SYNTHESIZED MRNA TO A DENATURING CONDITION, AND PURIFYING THE MRNA FROM THE IMPURE PREPARATION FROM STEP (A) BY TANGENTIAL FLOW FILTRATION, WHEREIN THE MRNA PURIFIED FROM STEP (B) IS SUBSTANTIALLY FREE OF PREMATURELY ABORTED RNA SEQUENCES AND/OR ENZYME REAGENTS USED IN IN VITRO SYNTHESIS.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/