AVACYN PHARMACEUTICALS INC.;THE ROCKEFELLER UNIVERSITY
发明人:
FISCHETTI, VINCENT, A.,GOLDBERG, ALLAN, R.,SCHUCH, RAYMOND
申请号：
EP13828087
公开号：
EP2882756A4
申请日:
2013.08.08
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The application describes targets and methods that can inhibit bacterial growth in Gram-positive and Gram-negative bacteria. A bacterial enzyme, 2-epimerase, is common to both Gram-positive and Gram-negative bacteria and contains an allosteric site that can be targeted to disrupt the enzyme. The allosteric site is present on the bacterial 2-epimerase, but the analogous mammalian enzyme does not contain the allosteric site, providing a route for attacking bacterial infections without affecting the mammalian enzyme.
