A flexible bag for biopharmaceutical use, includes a shell for receiving, in an inner space thereof, a flowable biopharmaceutical product, and flexible walls joined by fixed and sealed rigid-connection areas, two opposite walls being connected to each other by the peripheries thereof, at least one inlet port and one outlet port, a port being combined with a passage of the shell and mounted thereon by fixed and sealed connection elements, a plurality of similar outlet ports grouped together in a tapping area, a tapping wall provided with at least one opening for the passage and assembly of the outlet port for the similar outlet ports, fixed and sealed port-shell connection elements which are rigidly, fixedly, and sealingly connected to the tapping wall around the at least one opening for the passage and assembly of the outlet port, and an area for folding the two opposite walls.