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Prodrugs of retinoids and compounds similar to water-soluble retinoids with positive charge with very high skin penetration rates
专利权人:
Chongxi;Yu
发明人:
Yu, Chongxi
申请号:
ES07700593
公开号:
ES2596857T3
申请日:
2007.01.15
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compounds of Structure 1, ** Formula ** where R represents a linear chain - (CH2) n-, where n>; = 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 R1 and R2 are the same or different, and are independently selected from the group consisting of H, alkyl, alkyloxy, alkenyl or alkynyl residues having 1 to 12 carbon atoms, aryl or heteroaryl residues, or taken together are - (CH2 ) n-, where n>; = 2, 3, 4, 5, 6, 7, 8, 9, or 10; R3 is H; X represents O, S, or NH; X1 is selected from the group consisting of H, OH, Cl, Br, F, I, NO2, NO, CN, SO2R5, COR5, COOR5, NR6COR5, SOR5, SR5, PO3R6R6 ', C1-6 alkyl residues, C1 perfluoroalkyl -6, C1-6 alkenyl, C1-6 alkynyl, and C1-6 alkyloxy; X2 is selected from the group consisting of H, OH, Cl, Br, F, I, NO2, CN, SO2R5, COR5, COOR5, NR6COR5, SOR5, SR5, PO3R6R6 ', C1-6 alkyl residues, C1-6 perfluoroalkyl , C1-6 alkenyl, C1-6 alkynyl, and C1-6 alkyloxy; X3 is selected from the group consisting of H, OH, Cl, Br, F, I, NO2, CN, SO2R5, COR5, COOR5, NR6COR5, SOR5, SR5, PO3R6R6 ', C1-6 alkyl residues, C1-6 perfluoroalkyl , C1-6 alkenyl, C1-6 alkynyl, and C1-6 alkyloxy; X4 is selected from the group consisting of H, OH, Cl, Br, F, I, NO2, CN, SO2R5, COR5, COOR5, NR6COR5, SOR5, SR5, PO3R6R6 ', C1-6 alkyl residues, C1-6 perfluoroalkyl , C1-6 alkenyl, C1-6 alkynyl, and C1-6 alkyloxy; X5 is selected from the group consisting of H, OH, Cl, Br, F, I, NO2, CN, SO2R5, COR5, COOR5, NR6COR5, SOR5, SR5, PO3R6R6 ', C1-6 alkyl residues, C1-6 perfluoroalkyl , C1-6 alkenyl, C1-6 alkynyl, and C1-6 alkyloxy; X6 is selected from the group consisting of H, OH, Cl, Br, F, I, NO2, CN, SO2R5, COR5, COOR5, NR6COR5, SOR5, SR5, PO3R6R6 ', C1-6 alkyl residues, C1-6 perfluoroalkyl , C1-6 alkenyl, C1-6 alkynyl, and C1-6 alkyloxy; R5 is selected from the group consisting of H, OH, Cl, Br, F, I, NO2, CN, SO2R6, COR6, COOR6, NR6COR7, SOR6, SR6, PO3R6R6 ', C1-6 alkyl residues, C1-6 alkyloxy , C1-6 perfluoroalkyl, C1-6 alkenyl, C1-6 alkynyl, and C1-6 alkyl halide; R6 and R6 'are the sa
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