A compound that can be used as an MC4 receptor agonist is provided. [MEANS FOR SOLVING PROBLEMS] The present inventors have studied MC4 receptor agonists, confirmed that a piperazine derivative has an action, and completed the present invention. That is, the piperazine derivative of the present invention has an MC4 receptor agonistic action, and bladder / urinary tract diseases, in particular, low activity bladder, hypotonic bladder, asystolic bladder, detrusor hypoactivity, neurogenic bladder, It can be used as an agent for preventing and / or treating dysuria in urethral insufficiency, detrusor-external urinary sphincter coordination dysfunction and prostatic hypertrophy. [Selection figure] None【課題】MC4受容体アゴニストとして使用し得る化合物を提供する。【解決手段】本発明者らは、MC4受容体アゴニストについて検討し、ピペラジン誘導体が作用を有することを確認し、本発明を完成した。すなわち、本発明のピペラジン誘導体はMC4受容体アゴニスト作用を有し、膀胱・尿路系疾患、殊に、低活動膀胱、低緊張性膀胱、無収縮膀胱、排尿筋低活動、神経因性膀胱、尿道弛緩不全、排尿筋-外尿道括約筋協調不全及び前立腺肥大症における排尿障害の予防及び／又は治療剤として使用しうる。【選択図】なし
