University of Pittsburgh - Of the Commonwealth System of Higher Education
发明人:
Stephen Francis Badylak,George S. Hussey,Lindsey Tamiko Saldin,Mark Hikaru Murdock
申请号：
US16490056
公开号：
US20200069738A1
申请日:
2018.03.02
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Methods are disclosed for reducing the proliferation of a tumor cell, increasing apoptosis of a tumor cell, and/or decreasing migration of a tumor cell. These methods include contacting the tumor cell with an effective amount of solubilized ECM or a soluble fraction of extracellular matrix (ECM), thereby reducing the proliferation of the tumor cell, increasing apoptosis of the tumor cell, and/or decreasing migration of the tumor cell. Methods are also disclosed for treating a subject with a tumor. The methods include administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a soluble fraction of an ECM and a pharmaceutically acceptable carrier, thereby treating the tumor in the subject. In specific non-limiting examples, the tumor is a glioma and/or the ECM hydrogel is a urinary bladder ECM hydrogel.
